Hepatoid Variant of Pancreatic Cancer: Insights from a Case and Literature Review
DOI:
https://doi.org/10.6092/1590-8577/1476Keywords:
alpha-Fetoproteins, Carcinoma, Hepatocellular, Pancreatic NeoplasmsAbstract
Context “Hepatoid” cancer refers to an extrahepatic neoplasm with hepatocellular differentiation. The stomach is the most common site and pancreatic origin is distinctly uncommon. Case report We describe a patient with hepatoid pancreatic tumor who presented with inoperable metastatic disease. Conclusion Serum levels or tissue staining with alpha-fetoprotein (AFP) may not be a reliable tumor marker in these cases and an experienced pathologist and appropriate immunohistochemical staining are essential for early diagnosis. This report incorporates a comprehensive literature review outlining the clinical presentation, diagnostic difficulties, management and outcomes associated with this rare pathological entity.
Image: Liver biopsy.
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References
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